800 MHz NMR Spectrometer

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The 800 MHz NMR spectrometer is currently the highest field NMR spectrometer in the state of Oregon. The instrument is a 4-channel spectrometer equipped with a specially designed 5 mm TCI cryoprobe with Z-axis gradient, enabling improved sensitivity for ¹H, ¹⁹F, ¹³C and ¹⁵N detected solution state experiments. In addition, the system incorporates a 24 well sample case for improved automation. This spectrometer will primarily be used for the analysis of biological samples, leading to advances in research areas such as Alzheimer’s Disease and Cancer. Instrument time on the 800 MHz spectrometer is allocated via request.

Cryoprobe Complete Specs

Location: LPSC 175

700 MHz NMR Spectrometer

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This spectrometer features high sensitivity for natural products and chemistry. The instrument is a 2-channel spectrometer equipped with a 5 mm carbon observe cryoprobe with Z-axis gradient, providing high sensitivity for solution state carbon experiments. The spectrometer is primarily used for the analysis and characterization of natural products and newly synthesized organic compounds. Also available for this spectrometer are BBO and BBI probes. This instrument is one of the most sensitive carbon-detecting spectrometers in the world - capable of measuring a high quality carbon spectrum on 1000+ molecular weight samples containing as little as 0.1 mg.

Scheduling Guidelines: One hour maximum, noon to 6 pm Monday through Friday. Longer runs possible after consultation with NMR facility staff.

Location: LPSC 175

500 MHz NMR Spectrometer

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The 500 MHz instrument is a 4-channel spectrometer used for a wide range of solution state applications. A 5 mm BBOF probe and 5mm TXI triple resonance (HCN) probe, both equipped with Z-axis gradients, are available for this spectrometer. This spectrometer generally has the BBOF probe installed, but will occasionally have the TXI installed on an as needed basis. Please contact the NMR facility staff if you need the TXI probe. The sign next to the spectrometer computer indicates which probe is currently installed.

Scheduling Guidelines (when BBO is installed): No Restrictions

Scheduling Guidelines (when TXI is installed): No Restrictions

Location: Gilbert Addition 101

400 MHz NMR Spectrometers (2)

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These instruments are 2-channel NMR spectrometers used for solution state analysis. Available probes include 5mm BBO and 5 mm BBI probes, all with Z-axis gradients.

Scheduling Guidelines:

Robinson(LPSC): Monday through Friday, noon to 10 pm: No more than 2 consecutive 10 minute slots (20 minutes) per person per session.

Diels(ATAMI): No Restrictions

Location: LPSC 175 (Robinson), ATAMI (Diels)

Analytical Ultracentrifuge

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The facility also operates a Beckman Optima XL-A analytical Ultracentrifuge. This instrument is used to characterize particle sizes and behavior in solution. It is particularly valuable for the quantitative analysis of biomolecules, such as proteins and nucleic acids. It has broad applications in biophysics, such as determining protein homogeneity, polydispersity, association constants and equilibrium thermodynamic properties. In many cases, analysis with analytical ultracentrifugation is a desirable first step to characterizing a new protein sample, prior to NMR based structural analysis. Please contact Dr. Patrick Reardon for further information about accessing this instrument