OREGON STATE UNIVERSITY
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Work from the OSU Department of Biochemistry, OSU NMR Facility and University of Oregon reveals mechanistic insight into Dynein LC8 interactions with a multivalent IDP.
Work from OHSU, OSU and Johns Hopkins explores how metabolism impacts prostate cancer resistance to androgen targeted therapy.
Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays, we developed a model that proposes a concerted role of intrinsic disorder and multiple LC8 binding events in regulating LC8 transcription.
The jizanpeptins are depsipeptides isolated from a Red Sea Symploca cyanobacterium possessing potent and specific trypsin inhibition. These 1100 Da compounds were isolated in amounts ranging from 300 to 1000 micrograms making structure elucidation a significant challenge.
This work from the Nyarko lab provides structural and thermodynamic insights into the multivalent interactions of intrinsically disordered proteins
This paper describes the biochemical and structural characterization of the proposed common intermediate found during the biosynthesis of triazine-containing natural products. This is a further example of how common intermediates can be diversified by microorganisms into different products.
Recent work from the Barbar Lab published in the journal Structure provides novel atomic-level insights into the effect of phosphorylation in two broad and intertwined scientific areas: regulation of the molecular motor dynein and intrinsically disordered proteins.
Professor Elisar Barbar from the Biochemistry and Biophysics was interviewed as part of the Thought Leader Program by the online publication, News Medical.
OSU Installs the highest field NMR spectrometer in the state of Oregon, providing a powerful new tool for advancing research in biology and medicine.
1D-INADEQUATE useful in assigning substituted terphenyl molecular architectures