Multivalency regulates activity in an intrinsically disordered transcription factor

Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays, we developed a model that proposes a concerted role of intrinsic disorder and multiple LC8 binding events in regulating LC8 transcription.

Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea

The jizanpeptins are depsipeptides isolated from a Red Sea Symploca cyanobacterium possessing potent and specific trypsin inhibition. These 1100 Da compounds were isolated in amounts ranging from 300 to 1000 micrograms making structure elucidation a significant challenge.

Differential Binding Affinities and Allosteric Conformational Changes Underlie Interactions of Yorkie and a Multivalent PPxY Partner

This work from the Nyarko lab provides structural and thermodynamic insights into the multivalent interactions of intrinsically disordered proteins

Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase

This paper describes the biochemical and structural characterization of the proposed common intermediate found during the biosynthesis of triazine-containing natural products. This is a further example of how common intermediates can be diversified by microorganisms into different products.

Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay between Phosphorylation Site and Disordered Spliced Linkers.

Recent work from the Barbar Lab published in the journal Structure provides novel atomic-level insights into the effect of phosphorylation in two broad and intertwined scientific areas: regulation of the molecular motor dynein and intrinsically disordered proteins.

OSU Professor Elisar Barbar Interviewed in Thought Leader Program

Professor Elisar Barbar from the Biochemistry and Biophysics was interviewed as part of the Thought Leader Program by the online publication, News Medical.

OSU Installs 800 MHz NMR Spectrometer

OSU Installs the highest field NMR spectrometer in the state of Oregon, providing a powerful new tool for advancing research in biology and medicine.

Regioselective Suzuki couplings of non-symmetric dibromobenzenes: alkenes as regiochemical control elements

1D-INADEQUATE useful in assigning substituted terphenyl molecular architectures