OREGON STATE UNIVERSITY
Open search box
| Title | Total synthesis and conformational study of ovalifoliolatin B |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | M. Salih Q, Zakharov LN, Beaudry CM |
| Journal | Tetrahedron Letters |
| Volume | 61 |
| Pagination | 151988 |
| ISSN | 0040-4039 |
| Keywords | Conformational chirality, Reduction, total synthesis, Ullmann coupling |
| Abstract | The diaryletherheptanoid natural product, ovalifoliolatin B, was synthesized. The synthesis features a regioselective reduction of a conjugated dienone and an intramolecular Ullmann etherification. The conformation of the natural product was studied by dynamic NMR methods and by X-ray crystallography. Although the natural product structure is strained, it has a relatively low barrier for interconversion of enantiomeric conformations. |
| URL | http://www.sciencedirect.com/science/article/pii/S0040403920304317 |
| DOI | 10.1016/j.tetlet.2020.151988 |