Title | Total synthesis and conformational study of ovalifoliolatin B |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | M. Salih Q, Zakharov LN, Beaudry CM |
Journal | Tetrahedron Letters |
Volume | 61 |
Pagination | 151988 |
ISSN | 0040-4039 |
Keywords | Conformational chirality, Reduction, total synthesis, Ullmann coupling |
Abstract | The diaryletherheptanoid natural product, ovalifoliolatin B, was synthesized. The synthesis features a regioselective reduction of a conjugated dienone and an intramolecular Ullmann etherification. The conformation of the natural product was studied by dynamic NMR methods and by X-ray crystallography. Although the natural product structure is strained, it has a relatively low barrier for interconversion of enantiomeric conformations. |
URL | http://www.sciencedirect.com/science/article/pii/S0040403920304317 |
DOI | 10.1016/j.tetlet.2020.151988 |