|Title||Total synthesis and conformational study of ovalifoliolatin B|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||M. Salih Q, Zakharov LN, Beaudry CM|
|Keywords||Conformational chirality, Reduction, total synthesis, Ullmann coupling|
The diaryletherheptanoid natural product, ovalifoliolatin B, was synthesized. The synthesis features a regioselective reduction of a conjugated dienone and an intramolecular Ullmann etherification. The conformation of the natural product was studied by dynamic NMR methods and by X-ray crystallography. Although the natural product structure is strained, it has a relatively low barrier for interconversion of enantiomeric conformations.