TitleTotal Syntheses of Aromatic Abietane Diterpenoids Utilizing Advances in the Pummerer Rearrangement.
Publication TypeJournal Article
Year of Publication2018
AuthorsLi X, Carter RG
JournalOrg Lett
Volume20
Issue18
Pagination5546-5549
Date Published2018 09 21
ISSN1523-7052
Abstract

The first total syntheses of triptobenzene T, vitexifolin C, 4- epi-triptobenzene L, triptobenzene L, and nepetaefolin F have been accomplished through an enantioselective, common intermediate approach and have enabled the confirmation and/or establishment of the absolute stereochemistry of each natural product synthesized. Application of three new and/or underutilized Pummerer reaction pathways proved critical to the synthetic work. A proline sulfonamide-catalyzed Yamada-Otani reaction was used to access the highly functionalized cyclohexane A ring core, including the C all-carbon quaternary stereocenter. Additionally, the importance of the A ring unsaturation for controlling the stereoselectivity during the C alkylation is showcased.

DOI10.1021/acs.orglett.8b02060
Alternate JournalOrg. Lett.
PubMed ID30199260