|Title||Total Syntheses of Aromatic Abietane Diterpenoids Utilizing Advances in the Pummerer Rearrangement.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Li X, Carter RG|
|Date Published||2018 09 21|
The first total syntheses of triptobenzene T, vitexifolin C, 4- epi-triptobenzene L, triptobenzene L, and nepetaefolin F have been accomplished through an enantioselective, common intermediate approach and have enabled the confirmation and/or establishment of the absolute stereochemistry of each natural product synthesized. Application of three new and/or underutilized Pummerer reaction pathways proved critical to the synthetic work. A proline sulfonamide-catalyzed Yamada-Otani reaction was used to access the highly functionalized cyclohexane A ring core, including the C all-carbon quaternary stereocenter. Additionally, the importance of the A ring unsaturation for controlling the stereoselectivity during the C alkylation is showcased.
|Alternate Journal||Org. Lett.|