TitleSynthesis of Highly Substituted Phenols and Benzenes with Complete Regiochemical Control.
Publication TypeJournal Article
Year of Publication2020
AuthorsZhang X, Beaudry CM
JournalOrg Lett
Volume22
Issue15
Pagination6086-6090
Date Published2020 Aug 07
ISSN1523-7052
Abstract

Substituted phenols are requisite molecules for human health, agriculture, and diverse synthetic materials. We report a chemical synthesis of phenols, including penta-substituted phenols, that accommodates programmable substitution at any position. This method uses a one-step conversion of readily available hydroxypyrone and nitroalkene starting materials to give phenols with complete regiochemical control and in high chemical yield. Additionally, the phenols can be converted into highly and even fully substituted benzenes.

DOI10.1021/acs.orglett.0c02157
Alternate JournalOrg Lett
PubMed ID32687369