Title | Structure Characterization and Biological Activity of 2-Arylbenzofurans from an Indonesian Plant, (L.) Pers. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Noviany N, Samadi A, Yuliyan N, Hadi S, Aziz M, Purwitasari N, Mohamad S, Ismail NNajihah, Gable KP, Mahmud T |
Journal | Phytochem Lett |
Volume | 35 |
Pagination | 211-215 |
Date Published | 2020 Feb |
ISSN | 1874-3900 |
Abstract | A new 2-arylbenzofuran, sesbagrandiflorain C (), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (, 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (), sesbagrandiflorain A () and sesbagrandiflorain B (), have been isolated from the stem bark of an Indonesian plant, (L.) Pers. The chemical structure of compound was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against , , , and in an agar diffusion assay. However, sesbagrandiflorains A () and B () exhibited moderate activity against H37Rv. In addition, compounds - have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines. |
DOI | 10.1016/j.phytol.2019.12.008 |
Alternate Journal | Phytochem Lett |
PubMed ID | 32863985 |
PubMed Central ID | PMC7451414 |
Grant List | S10 OD018518 / OD / NIH HHS / United States |