TitleStructure Characterization and Biological Activity of 2-Arylbenzofurans from an Indonesian Plant, (L.) Pers.
Publication TypeJournal Article
Year of Publication2020
AuthorsNoviany N, Samadi A, Yuliyan N, Hadi S, Aziz M, Purwitasari N, Mohamad S, Ismail NNajihah, Gable KP, Mahmud T
JournalPhytochem Lett
Volume35
Pagination211-215
Date Published2020 Feb
ISSN1874-3900
Abstract

A new 2-arylbenzofuran, sesbagrandiflorain C (), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (, 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (), sesbagrandiflorain A () and sesbagrandiflorain B (), have been isolated from the stem bark of an Indonesian plant, (L.) Pers. The chemical structure of compound was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against , , , and in an agar diffusion assay. However, sesbagrandiflorains A () and B () exhibited moderate activity against H37Rv. In addition, compounds - have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines.

DOI10.1016/j.phytol.2019.12.008
Alternate JournalPhytochem Lett
PubMed ID32863985
PubMed Central IDPMC7451414
Grant ListS10 OD018518 / OD / NIH HHS / United States