Nuclear Magnetic Resonance Facility

A new 2-arylbenzofuran, sesbagrandiflorain C (), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (, 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (), sesbagrandiflorain A () and sesbagrandiflorain B (), have been isolated from the stem bark of an Indonesian plant, (L.) Pers. The chemical structure of compound was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against , , , and in an agar diffusion assay. However, sesbagrandiflorains A () and B () exhibited moderate activity against H37Rv. In addition, compounds - have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines.