TitleRegioselective Synthesis of Substituted Carbazoles, Bicarbazoles, and Clausine C.
Publication TypeJournal Article
Year of Publication2021
AuthorsPoints GL, Beaudry CM
JournalOrg Lett
Volume23
Issue17
Pagination6882-6885
Date Published2021 09 03
ISSN1523-7052
Abstract

Substituted carbazoles are efficiently constructed from 3-triflato-2-pyrones and alkynyl anilines. Multiple substituents are tolerated on the carbazole, and complete control of regiochemistry is observed. Complicated and sterically congested substitution patterns are produced. This strategy is also used to prepare substituted bicarbazoles and related biaryls. Finally, the method was showcased in a synthesis of the carbazole natural product clausine C.

DOI10.1021/acs.orglett.1c02449
Alternate JournalOrg Lett
PubMed ID34424701