TitleModeling framework for isotopic labeling of heteronuclear moieties.
Publication TypeJournal Article
Year of Publication2017
AuthorsBorkum MI, Reardon PN, Taylor RC, Isern NG
JournalJ Cheminform
Volume9
Pagination14
Date Published2017
ISSN1758-2946
Abstract

BACKGROUND: Isotopic labeling is an analytic technique that is used to track the movement of isotopes through reaction networks. In general, the applicability of isotopic labeling techniques is limited to the investigation of reaction networks that consider homonuclear moieties, whose atoms are of one tracer element with two isotopes, distinguished by the presence of one additional neutron.

RESULTS: This article presents a reformulation of the modeling framework for isotopic labeling, generalized to arbitrarily large, heteronuclear moieties, arbitrary numbers of isotopic tracer elements, and arbitrary numbers of isotopes per element, distinguished by arbitrary numbers of additional neutrons.

CONCLUSIONS: With this work, it is now possible to simulate the isotopic labeling states of metabolites in completely arbitrary biochemical reaction networks.

DOI10.1186/s13321-017-0201-7
Alternate JournalJ Cheminform
PubMed ID28303165
PubMed Central IDPMC5337233