TitleHigh-resolution microstrip NMR detectors for subnanoliter samples.
Publication TypeJournal Article
Year of Publication2017
AuthorsChen Y, Mehta HS, Butler MC, Walter ED, Reardon PN, Renslow RS, Mueller KT, Washton NM
JournalPhys Chem Chem Phys
Volume19
Issue41
Pagination28163-28174
Date Published2017 Oct 25
ISSN1463-9084
Abstract

We present the numerical optimization and experimental characterization of two microstrip-based nuclear magnetic resonance (NMR) detectors. The first detector, introduced in our previous work, was a flat wire detector with a strip resting on a substrate, and the second detector was created by adding a ground plane on top of the strip conductor, separated by a sample-carrying capillary and a thin layer of insulator. The dimensional parameters of the detectors were optimized using numerical simulations with regards to radio frequency (RF) sensitivity and homogeneity, with particular attention given to the effect of the ground plane. The influence of copper surface finish and substrate surface on the spectral resolution was investigated, and a resolution of 0.8-1.5 Hz was obtained on 1 nL deionized water depending on sample positioning. For 0.13 nmol sucrose (0.2 M in 0.63 nL HO) encapsulated between two Fluorinert plugs, high RF homogeneity (A/A= 70-80%) and high sensitivity (expressed in the limit of detection nLOD= 0.73-1.21 nmol s) were achieved, allowing for high-performance 2D NMR spectroscopy of subnanoliter samples.

DOI10.1039/c7cp03933f
Alternate JournalPhys Chem Chem Phys
PubMed ID29022609