Title | Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Zhu C, Lew CI, Neuhaus GF, Adpressa DA, Zakharov LN, Kaweesa EN, Plitzko B, Loesgen S |
Journal | Chem Biodivers |
Date Published | 2021 Feb 26 |
ISSN | 1612-1880 |
Abstract | From arid, high desert soil samples collected near Bend, Oregon, 19 unique bacteria were isolated. Each strain was identified by 16S rRNA gene sequencing, and their organic extracts were tested for antibacterial and antiproliferative activities. Noteworthy, six extracts (30 %) exhibited strong inhibition resulting in less than 50 % cell proliferation in more than one cancer cell model, tested at 10 μg/mL. Principal component analysis (PCA) of LC/MS data revealed drastic differences in the metabolic profiles found in the organic extracts of these soil bacteria. In total, fourteen potent antibacterial and/or cytotoxic metabolites were isolated via bioactivity-guided fractionation, including two new natural products: a pyrazinone containing tetrapeptide and 7-methoxy-2,3-dimethyl-4H-chromen-4-one, as well as twelve known compounds: furanonaphthoquinone I, bafilomycin C1 and D, FD-594, oligomycin A, chloramphenicol, MY12-62A, rac-sclerone, isosclerone, tunicamycin VII, tunicamycin VIII, and (6S,16S)-anthrabenzoxocinone 1.264-C. |
DOI | 10.1002/cbdv.202100046 |
Alternate Journal | Chem Biodivers |
PubMed ID | 33636028 |
Grant List | / / Oregon State University's NMR Facility / 1S10OD018518 / NH / NIH HHS / United States #2014162 / / M. J. Murdock Charitable Trust / |