TitleBiodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria.
Publication TypeJournal Article
Year of Publication2021
AuthorsZhu C, Lew CI, Neuhaus GF, Adpressa DA, Zakharov LN, Kaweesa EN, Plitzko B, Loesgen S
JournalChem Biodivers
Date Published2021 Feb 26
ISSN1612-1880
Abstract

From arid, high desert soil samples collected near Bend, Oregon, 19 unique bacteria were isolated. Each strain was identified by 16S rRNA gene sequencing, and their organic extracts were tested for antibacterial and antiproliferative activities. Noteworthy, six extracts (30 %) exhibited strong inhibition resulting in less than 50 % cell proliferation in more than one cancer cell model, tested at 10 μg/mL. Principal component analysis (PCA) of LC/MS data revealed drastic differences in the metabolic profiles found in the organic extracts of these soil bacteria. In total, fourteen potent antibacterial and/or cytotoxic metabolites were isolated via bioactivity-guided fractionation, including two new natural products: a pyrazinone containing tetrapeptide and 7-methoxy-2,3-dimethyl-4H-chromen-4-one, as well as twelve known compounds: furanonaphthoquinone I, bafilomycin C1 and D, FD-594, oligomycin A, chloramphenicol, MY12-62A, rac-sclerone, isosclerone, tunicamycin VII, tunicamycin VIII, and (6S,16S)-anthrabenzoxocinone 1.264-C.

DOI10.1002/cbdv.202100046
Alternate JournalChem Biodivers
PubMed ID33636028
Grant List / / Oregon State University's NMR Facility /
1S10OD018518 / NH / NIH HHS / United States
#2014162 / / M. J. Murdock Charitable Trust /