Submitted by reardonp on Fri, 06/01/2018 - 10:21
TitleAsymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols.
Publication TypeJournal Article
Year of Publication2018
AuthorsBrumsted CJ, Carpenter EL, Indra AK, Mahmud T
JournalOrg Lett
Volume20
Issue2
Pagination397-400
Date Published2018 Jan 19
ISSN1523-7052
Abstract

Pactamycin is a structurally unique aminocyclitol antibiotic with broad-spectrum cell growth inhibitory activity. To explore the bountiful activity of the aminocyclitol core of pactamycin, an efficient, modular, and asymmetric synthesis of aminocyclopentitols resembling the pactamycin pharmacophore has been developed employing a SmI-mediated imino-pinacol coupling strategy. Two of the compounds exhibited antitumor activity against A375 melanoma cells.
DOI10.1021/acs.orglett.7b03681
Alternate JournalOrg. Lett.
PubMed ID29319326