Title | Asymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Brumsted CJ, Carpenter EL, Indra AK, Mahmud T |
Journal | Org Lett |
Volume | 20 |
Issue | 2 |
Pagination | 397-400 |
Date Published | 2018 Jan 19 |
ISSN | 1523-7052 |
Abstract | Pactamycin is a structurally unique aminocyclitol antibiotic with broad-spectrum cell growth inhibitory activity. To explore the bountiful activity of the aminocyclitol core of pactamycin, an efficient, modular, and asymmetric synthesis of aminocyclopentitols resembling the pactamycin pharmacophore has been developed employing a SmI-mediated imino-pinacol coupling strategy. Two of the compounds exhibited antitumor activity against A375 melanoma cells. |
DOI | 10.1021/acs.orglett.7b03681 |
Alternate Journal | Org. Lett. |
PubMed ID | 29319326 |