TitleAntibacterial Drimane Sesquiterpenes from .
Publication TypeJournal Article
Year of Publication2020
AuthorsNeuhaus GF, Loesgen S
JournalJ Nat Prod
Date Published2020 Dec 21
ISSN1520-6025
Abstract

Bioactivity-guided isolation of led to the discovery of five new drimane sesquiterpenes, named ustusal A, ustusolate F and G, and ustusoic acid A and B, - respectively. Structural elucidation of these fungal terpenes relied on 1D and 2D NMR techniques, high-resolution mass spectrometry, and chiroptical properties. Their relative configurations were determined by NMR methods, while the absolute configurations were established using comparative analyses of computed and experimental NMR chemical shifts and ECD spectra. The sesquiterpenes exhibited weak activity against the clinically relevant pathogens vancomycin-resistant and multidrug-resistant ; however, the activity of was drastically enhanced when equal amounts of stromemycin (), a known metabolite coisolated from the same fraction from , was added.

DOI10.1021/acs.jnatprod.0c00910
Alternate JournalJ Nat Prod
PubMed ID33346651